MUTATION IN THE TWO-COMPONENT REGULATOR BAESR MEDIATES CEFIDEROCOL RESISTANCE AND ENHANCES VIRULENCE IN ACINETOBACTER BAUMANNII

Mutation in the two-component regulator BaeSR mediates cefiderocol resistance and enhances virulence in Acinetobacter baumannii

ABSTRACT Acinetobacter baumannii has become one of the most challenging pathogens in many countries with limited treatment options available.Cefiderocol, a novel siderophore-conjugated cephalosporin, shows potent in vitro activity against A.baumannii, including isolates houston texans shorts resistant to carbapenems.To date, few reports on the mech

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High prevalence of Schistosoma japonicum and Fasciola gigantica in bovines from Northern Samar, the Philippines.

The cause of zoonotic schistosomiasis in the Philippines is Schistosoma japonicum, which infects up to 46 mammalian hosts, including humans and bovines.In China, water buffaloes have been identified as major reservoir hosts for schistosomiasis japonica, contributing up to 75% of human transmission.In the Philippines, water buffaloes (carabao; Bubal

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Roles of Rap1 signaling in tumor cell migration and invasion

Ras-associated protein-1 (Rap1), a small GTPase in the Ras-related protein family, is an important regulator of click here basic cellular functions (e.g., formation and control of cell adhesions and junctions), cellular migration, and polarization.Through its interaction with other proteins, Rap1 plays many roles during cell invasion and metastasis

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